Search results for " integrity"

Synthesis of habitat restoration impacts on young-of-the-year salmonids in boreal rivers

2019

River restoration offers the potential to enhance biological integrity, often measured as fish population changes. We used a meta-analytical approach to synthesize density responses to in-stream habitat restoration by young-of-the year (YOY) brown trout and Atlantic salmon in 28 rivers (overall 32 restoration projects) in Finland. We also examined which local and watershed-scale factors most influenced restoration success. Finally, we conducted an expert survey to obtain an independent estimate of a sufficient density enhancement for restoration to be considered successful. Despite strong context-dependency, habitat restoration had an overall positive effect on YOY salmonid density. When co…

Advanced Machining Processes

2017

This chapter provides comprehensive knowledge regarding both well-established achievements in manufacturing and new trends in improving machining processes, taking into account physical, design and technological aspects. The background of machining advancements is outlined, including all components of the machining system and typical machining operations such as turning, milling and drilling and different construction materials. In particular, this short survey covers such machining techniques as high-speed machining/cutting (HSM/HSC), hard part machining, dry and near-dry machining (MQL), high-performance machining (HPM), multitasking/complete machining, and assisted and hybrid machining. …

On the optimization of the cutting conditions for an improved corrosion resistance of OFHC copper

2018

International audience; Machining has a particular impact on the surface integrity and on corrosion resistance of components. In fact, material removal induces geometrical, mechanical and micro-structural modifications in the machined surface and sub-surface that alter the electrochemical behavior of the material, and so the aging process. In this study, oxygen free high conductivity copper (OFHC) has machined under orthogonal cutting conditions using uncoated cemented carbide tools. Then, the corrosion resistance in 0.1 M NaCl salt fog atmosphere of the machined samples is analyzed. Finally, the optimal cutting conditions, including the tool geometry, for an improved corrosion resistance a…

Improving surface integrity of additively manufactured GP1 stainless steel by roller burnishing

2020

Abstract Additive manufacturing can rapidly fabricate the desired components by selectively melting and solidifying feedstock, rather than conventional subtractive machining. However, the difference between the two routes in terms of surface integrity of the final component is relevant. This paper presents a strategy to control the surface characteristics of additively manufactured stainless steel by roller burnishing. In particular, process parameters have been carefully selected to improve the surface integrity of the worked material. The quality of the surface has been analyzed in terms of roughness, hardness, microstructure and residual stresses. The overall product endurance under high…

Friction Model for Tool/Work Material Contact Applied to Surface Integrity Prediction in Orthogonal Cutting Simulation

2017

Abstract Tribological behavior at both tool/chip and tool/work material interfaces should be highly considered while simulating the machining process. In fact, it is no longer accurate to suppose one independent constant friction coefficient at the tool/chip interface, since in reality it depends on the applied contact conditions, including the sliding velocity and pressure. The contact conditions at both above mentioned interfaces may affect the thermal and mechanical phenomena and consequently the surface integrity predictions. In this article, the influence of contact conditions (sliding velocity) on the tribological behavior of uncoated tungsten carbide tool against OFHC copper work mat…

Cortical network fingerprints predict deep brain stimulation outcome in dystonia.

2018

AbstractBackgroundDeep brain stimulation (DBS) is an effective evidence-based therapy for dystonia. However, no unequivocal predictors of therapy responses exist. We investigate whether patients optimally responding to DBS present distinct brain network organization and structural patterns.MethodsBased on a German multicentre cohort of eighty-two dystonia patients with segmental and generalized dystonia, who received DBS implantation in the globus pallidus internus patients were classified based on the clinical response 36 months after DBS, as superior-outcome group or moderate-outcome group, as above or below 70% motor improvement, respectively. Fifty-one patients met MRI-quality and treat…

Peculiarities of studying the effects of pathogen reduction technologies on platelets.

2016

The transfusion of platelet concentrates (PCs) is mainly used for treatment of thrombocytopenic, trauma or surgery patients. The integrity and safety of these platelet preparations, however, is compromised by the presence of pathogens, such as viruses, bacteria and parasites. The transfer of allogeneic donor leukocytes contaminating PCs can also potentially cause adverse reactions in recipients. These considerations prompted the development and implementation of pathogen reduction technologies (PRT), which are based on chemically induced cross-linking and inactivation of nucleic acids. While the incumbent PRT may provide some protection against transfusion-transmitted infections, they are i…

2016

RNA 2'-O-methylation is one of the ubiquitous nucleotide modifications found in many RNA types from Bacteria, Archaea and Eukarya. RNAs bearing 2'-O-methylations show increased resistance to degradation and enhanced stability in helices. While the exact role of each 2'-O-Me residue remained elusive, the catalytic protein Fibrillarin (Nop1 in yeast) responsible for 2'-O-methylation in eukaryotes, is associated with human pathologies. Therefore, there is an urgent need to precisely map and quantify hundreds of 2'-O-Me residues in RNA using high-throughput technologies. Here, we develop a reliable protocol using alkaline fragmentation of total RNA coupled to a commonly used ligation approach, …

Caretakers and Gatekeepers

2017

It has now been generally accepted that the genes responsible for familial cancer syndromes can be divided into two categories, known as caretakers and gatekeepers. Caretakers are genes that control the maintenance of the genetic information integrity in each cell while gatekeepers are those genes which directly regulate tumor growth, codifying for proteins which either stimulate or inhibit proliferation, differentiation or apoptosis. Keywords: gatekeeper genes; caretaker genes; tumor suppressor genes; cell cycle; hereditary syndromes

Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex

2017

AbstractWhile deep brain stimulation of the subthalamic nucleus (STN-DBS) has evolved to an evidence-based standard treatment for Parkinson’s disease (PD), the targeted cerebral networks are poorly described and no objective predictors for the postoperative clinical response exist. To elucidate the systemic mechanisms of DBS, we analysed cerebral grey matter properties using cortical thickness measurements and addressed the dependence of structural integrity on clinical outcome. Thirty one patients with idiopathic PD without dementia (23 males, age: 63.4 ± 9.3, Hoehn and Yahr: 3.5 ± 0.8) were selected for DBS treatment. The patients underwent whole-brain preoperative T1 MR-Imaging at 3 T. G…